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  • Feature GSK3β plays an essential role in Ras degradation and that inhibition of this degradation pathway by aberrant Wnt/β-catenin signaling may contribute to Ras-induced transformation in colorectal tumorige
    Application WB,IP,IHC
    Species Homo sapiens
    Targets H-Ras
    Title Ras stabilization through aberrant activation of Wnt/β-catenin signaling promotes intestinal tumorigenesis.
    Publication Jeong WJ, Sci Signal, 2012
    Methods Phospho-T144/T148 H-Ras polyclonal antibodies were generated by immunizing rabbits with a keyhole limpet hemocyanin (KLH) carrier protein–conjugated phosphorylated peptide (residues 140 to 152; PYIEpTSAKpTRQGV; Abmart Inc.).