Feature |
CGG repeat expansion in the 5'UTR of FMR1 is thought to elicit toxicity as RNA. |
Application |
WB, IHC |
Species |
Mus musculus |
Targets |
FMR1 |
Catergory |
RNA binding |
Title |
CGG repeat-associated translation mediates neurodegeneration in fragile X tremor ataxia syndrome. |
Publication |
Henry L. Paulson, Neuron, 2013 |
Methods |
Monoclonal mouse antibodies 2J7 and 2C13 were developed commercially (Abmart) against a 10 amino acid peptide, LAGLKRRWRS, in the predicted carboxyl terminus of the FMR1polyG. |
Figures |
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Highlights |
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