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  • Feature CGG repeat expansion in the 5'UTR of FMR1 is thought to elicit toxicity as RNA.
    Application WB, IHC
    Species Mus musculus
    Targets FMR1
    Catergory RNA binding
    Title CGG repeat-associated translation mediates neurodegeneration in fragile X tremor ataxia syndrome.
    Publication Henry L. Paulson, Neuron, 2013
    Methods Monoclonal mouse antibodies 2J7 and 2C13 were developed commercially (Abmart) against a 10 amino acid peptide, LAGLKRRWRS, in the predicted carboxyl terminus of the FMR1polyG.