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  • Feature L1 RNP is linked by a both protein-protein (PCNA) and protein-RNA (UPF1) interactions; PCNA binds to ORF2p via a PIP box and is critical for retrotransposition.
    Application WB
    Species Homo sapiens
    Targets ORF1
    Catergory RNA binding
    Title Affinity proteomics reveals human host factors implicated in discrete stages of LINE-1 retrotransposition.
    Publication Taylor MS, Cell, 2013
    Methods Mouse monoclonal anti-human L1 ORF1 clone 4H1 was purchased from ABmart.