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  • Feature Impaired granulocyte PKA function in AERD may lead to dysregulated control of 5-lipoxygenase activity by prostaglandin E2.
    Application FACS
    Species Homo sapiens
    Targets EP2R(E prostanoid2)
    Catergory GPCR
    Title Prostaglandin E2 resistance in granulocytes from patients with aspirin-exacerbated respiratory disease
    Publication Laidlaw TM, J Allergy Clin Immunol, 2014
    Methods EP2 receptor expression was analyzed on permeabilized whole blood by using a mouse anti-human monoclonal antibody directed against a fusion peptide based on extracellular portions of the human EP2 receptor (Abmart,Shanghai, China)