| Feature | Src-mediated PSD-95 phosphorylation activates NMDA receptor. |
| Application | Blocking |
| Species | Homo sapiens |
| Targets | phospho-PSD-95Y523 |
| Catergory | |
| Title | The Upregulation of NR2A-Containing N-Methyl-D-Aspartate Receptor Function by Tyrosine Phosphorylation of Postsynaptic Density 95 Via Facilitating Src/Proline-Rich Tyrosine Kinase 2 Activation |
| Publication | Xiao-Yu Hou, Mol Neurobiol, 2014 |
| Methods | A rabbit polyclonal antibodyagainst phospho-PSD-95Y523 (pY523) was raised inNew Zealand white rabbits with a keyhole limpethemocyanin-conjugated pY-containing synthetic peptide(REDSVLSpYETVT) as immunogen, and then purifiedby two-step immunoaffinity chromatography using a columnconjugated to the non-phosphopeptide to eliminateantibodies against nonphosphorylated PSD-95, followedby purification with another column conjugated with theimmunogen (AbMART, Shanghai, China) |
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| Highlights |
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