| Feature | A novel monoclonal antibody, which binds to human TCRα constant region, with specificity for a denatured epitope that can be visualized by Western blot. |
| Application | WB, IP |
| Species | Homo sapiens |
| Targets | TCRα |
| Catergory | Signaling |
| Title | Detection of Constant Domain of Human T Cell Antigen Receptor Alpha-Chain Via Novel Monoclonal Antibody 7F18 |
| Publication | Reed BK, Monoclon Antib Immunodiagn Immunother, 2014 |
| Methods | We submitted the peptide sequence QLRDSKSSDK to Abmart, Inc. (Shanghai, China), which passed their in-house,bioinformatic predictive algorithm criteria as possessing adequate antigenicity for MAb development. By contractual agreement, Abmart synthesized the peptide and used it to immunize mice and generate a panel of MAb-secreting candidate hybridomas that our laboratory screened for the desired assay functionality and speci?city. Abmart’s role was limited to MAb generation, and the company retained no intellectual property rights that could limit or otherwise control dissemination of the MAb to the scienti?c community. |
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