| Feature | Identifies a bidirectional (phosphorylation and dephosphorylation) regulatory mechanism controlling Tiam1 stability. |
| Application | WB, IP |
| Species | Homo sapiens |
| Targets | Tiam1 |
| Catergory | Guanyl-nucleotide exchange factor |
| Title | An EGFR/PI3K/AKT axis promotes accumulation of the Rac1-GEF Tiam1 that is critical in EGFR-driven tumorigenesis |
| Publication | Zhu G, Oncogene, 2015 |
| Methods | A polyclonal antibody against phosphor-serine 231 of Tiam1 was generated by Abmart (www.ab-mart.com.cn) through immunizing rabbits with two peptides (CQRANSLGDLY and CQRAN(pS)LGDLY) and phosphor-specific antibody was affinity purified. ... |
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