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  • Feature Identifies a bidirectional (phosphorylation and dephosphorylation) regulatory mechanism controlling Tiam1 stability.
    Application WB, IP
    Species Homo sapiens
    Targets Tiam1
    Catergory Guanyl-nucleotide exchange factor
    Title An EGFR/PI3K/AKT axis promotes accumulation of the Rac1-GEF Tiam1 that is critical in EGFR-driven tumorigenesis
    Publication Zhu G, Oncogene, 2015
    Methods A polyclonal antibody against phosphor-serine 231 of Tiam1 was generated by Abmart (www.ab-mart.com.cn) through immunizing rabbits with two peptides (CQRANSLGDLY and CQRAN(pS)LGDLY) and phosphor-specific antibody was affinity purified. ...