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  • Feature Hh-Gli2 signaling markedly increases Igf2 mRNA and activates the Igf-mTORC2-Akt signaling cascade.
    Application WB
    Species Mus musculus
    Targets Gli2
    Catergory Transcription related
    Title Hedgehog signaling activates a positive feedback mechanism involving insulin-like growth factors to induce osteoblast differentiation
    Publication Shi Y, Proc Natl Acad Sci, 2015
    Methods A monoclonal antibody specific for full-length Gli2 was generated against a peptide within the C-terminal half of mouse Gli2 according to proprietary techniques (Abmart).