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  • Feature Reveal a new mechanism for SAMHD1 to control LINE-1 by activating cellular stress granule pathway.
    Application WB,IF
    Species Homo sapiens
    Targets ORF1p
    Catergory Nucleotide binding
    Title SAMHD1 Inhibits LINE-1 Retrotransposition by Promoting Stress Granule Formation
    Publication Hu S, PLoS Genet, 2015
    Methods The purified ORF1p was used to immunize rabbits. Rabbit serum was collected, purified via affinity chromatography (Abmart, Inc) and tested for their recognition of ORF1p in western blotting and immunofluorescence staining.