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    SEAL™ antigen design begins with your intended antibody end-uses in mind. While a Western blotting antibody binds to unfolded/denatured protein state, a flow cytometry antibody for a receptor or a CHIP antibody for a transcription factor needs to recognize the right sequences on the native protein.? SEAL™ antigens are designed to be 10-12 amino acids in length so they will have 1-2 independent antibody-binding epitopes. These (unstructured) antigens have the same conformation as it is in the native (naturally unstructured) and denatured protein state (unstructured after sample treatment), therefore are capable of producing antibodies to bind to denatured/unfolded proteins in WB/IHC/IF or folded/native proteins in IP/CHIP/flow cytometry.